A brief history of [T.sub.H]17, the first major revision in the [T.sub.H]1/[T.sub.H]2 hypothesis of T cell-mediated tissue damage
Article Abstract:
The T-helper 17 ([T.sub.H]17) and the [T.sub.H]1/[T.sub.H]2 hypothesis of T cell-mediated tissue damage in both autoimmunity and immunity triggered by microbial infection are discussed. The analysis has suggested that the [T.sub.H]17 hypothesis will undergo modification and will almost certainly evolve into an even more intricate story, as immunologists dissect the exquisitely orchestrated mechanisms inherent in tissue damage in response to microbial infections.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein
Article Abstract:
A sensitive assay is developed based on self-assembling radiolabeled tetramers that allow discrimination of antibodies against folded or denatured myelin oligodendrocyte glycoprotein (MOG) by selective unfolding of the antigen domain. Results show that MOG-specific autoantibodies are identified in a subset of acute disseminated encephalomyelitis (ADEM) but very rarely in adult-onset multiple sclerosis (MS) cases.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population
Article Abstract:
A monoclonal antibody against cytotoxic T-lymphocyte antigen 4 (CTLA-4) will enhance or inhibit clonal expansion of different T cells depending on the T-cell activation state and the strength of the T-cell receptor signal. This information could be used to influence the immune response in order to treat disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Upregulation of PD-1 expression on HIV-specific CD[8.sup.+] T cells leads to reversible immune dysfunction. Taking the brake off T cells in chronic viral infection
- Abstracts: 'Cash-strapped hospitals could help save the world'. Improving provision of cardiac rehabilitation services. 'Wasting medicines often starts the moment a prescription is generated'
- Abstracts: Role of the breast care nurse specialist in a diagnostic clinic. The development and audit of a nurse-led urology/oncology clinic
- Abstracts: How dentistry weathers a slow economy. Gauging the success of your practice
- Abstracts: New methods suggest AIDS toll lower than estimated. HIV and AIDS: 20 years of science